According to IMS Health ; Spending on medicines will reach nearly $1,100Bn in 2015, reflecting a slowing growth rate of 3-6% over the five year period compared to 6.2% annual growth over the past five years. The U.S. share of global spending will decline from 41% in 2005 to 31% in 2015. All of the increase in spending on brands – both new and existing – will be offset by patent expiries which will reduce brand spending by $120Bn through 2015.